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Although Jane Leeves and David Hyde Pierce will not be reprising their roles as Daphne and Niles Crane, Peri Gilpin and Bebe Neuwirth were recently announced to be returning as Roz Doyle and Lilith Sternin respectively.
Pierce's snootier character was the subject of many interesting plots in the main series, including his compelling will-they/won't-they romance with Jane Leeves' Daphne.
Source: https://screenrant.com/frasier-reboot-original-ending-david-hyde-pierce-niles/
This eased concerns about David Hyde Pierce and Jane Leeves' decision to turn down the project.
Source: https://screenrant.com/frasier-reboot-show-lilith-bebe-neuwirth-first-look-return-video/